Physicians’ ordering Benadryl: Epinephrine is the first line treatment of anaphylaxis. This must be reflected in allergy action plans. Antihistamines are second line and if used, should only be used in conjunction with epinephrine in the treatment of anaphylaxis.Antihistamines are slow to act (30-60 minutes), have no effect on platelet activating factor, leukotrienes, prostoglandins, or other mediators, and are ineffective for GI, respiratory, and circulatory symptoms. . Additionally, there is no high quality evidence either for or against the use of H1-antihistamines in anaphylaxis as per a recent Cochrane Review.
An additional consideration is the importance of a child’s participation in food allergy management that will help them develop skills that they will inevitably need when they leave their school.
Education regarding biphasic reactions and the potential need for additional epinephrine: Some episodes of anaphylaxis may be biphasic, where there is a return of anaphylaxis after the resolution of symptoms. It is difficult to predict which patients may experience a biphasic reaction, but there seems to be increased likelihood with increased severity, higher epinephrine requirements, and in cases where there was a delayed administration of epinephrine. . Taking the biphasic reaction into account, students should be taken by ambulance to the emergency department and observed for a minimum of four to six hours, with longer observation times and hospital admissions for severe symptoms . In addition to the potential for a biphasic reaction, episodes of anaphylaxis may require more than one dose of epinephrine, supporting recommendations to have two doses available
Written by: Michael Pistiner MD, MMSc and Anne H. Sheetz RN, MPH, NEA-BC.
This piece was originally published in the American Academy of Pediatrics, Council on School Health, Spring/Summer 2009 Newsletter.
We thank the AAP for granting permission to post and to update mandated reporting data within this article.